68 research outputs found
Topological regluing of rational functions
Regluing is a topological operation that helps to construct topological
models for rational functions on the boundaries of certain hyperbolic
components. It also has a holomorphic interpretation, with the flavor of
infinite dimensional Thurston--Teichm\"uller theory. We will discuss a
topological theory of regluing, and trace a direction in which a holomorphic
theory can develop.Comment: 38 page
Metal-insulator and magnetic transition of NiO at high pressures
Published versio
Theory and Applications of Non-Relativistic and Relativistic Turbulent Reconnection
Realistic astrophysical environments are turbulent due to the extremely high
Reynolds numbers. Therefore, the theories of reconnection intended for
describing astrophysical reconnection should not ignore the effects of
turbulence on magnetic reconnection. Turbulence is known to change the nature
of many physical processes dramatically and in this review we claim that
magnetic reconnection is not an exception. We stress that not only
astrophysical turbulence is ubiquitous, but also magnetic reconnection itself
induces turbulence. Thus turbulence must be accounted for in any realistic
astrophysical reconnection setup. We argue that due to the similarities of MHD
turbulence in relativistic and non-relativistic cases the theory of magnetic
reconnection developed for the non-relativistic case can be extended to the
relativistic case and we provide numerical simulations that support this
conjecture. We also provide quantitative comparisons of the theoretical
predictions and results of numerical experiments, including the situations when
turbulent reconnection is self-driven, i.e. the turbulence in the system is
generated by the reconnection process itself. We show how turbulent
reconnection entails the violation of magnetic flux freezing, the conclusion
that has really far reaching consequences for many realistically turbulent
astrophysical environments. In addition, we consider observational testing of
turbulent reconnection as well as numerous implications of the theory. The
former includes the Sun and solar wind reconnection, while the latter include
the process of reconnection diffusion induced by turbulent reconnection, the
acceleration of energetic particles, bursts of turbulent reconnection related
to black hole sources as well as gamma ray bursts. Finally, we explain why
turbulent reconnection cannot be explained by turbulent resistivity or derived
through the mean field approach.Comment: 66 pages, 24 figures, a chapter of the book "Magnetic Reconnection -
Concepts and Applications", editors W. Gonzalez, E. N. Parke
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Appetite and energy balance signals from adipocytes
Interest in the biology of white adipose tissue has risen markedly with the recent surge in obesity and its associated disorders. The tissue is no longer viewed simply as a vehicle for lipid storage; instead, it is recognized as a major endocrine and secretory organ. White adipocytes release a multiplicity of protein hormones, signals and factors, termed adipokines, with an extensive range of physiological actions. Foremost among these various adipokines is the cytokine-like hormone, leptin, which is synthesized predominantly in white fat. Leptin plays a critical role in the control of appetite and energy balance, with mutations in the genes encoding the hormone or its receptor leading to profound obesity in both rodents and man. Leptin regulates appetite primarily through an interaction with hypothalamic neuroendocrine pathways, inhibiting orexigenic peptides such as neuropeptide Y and orexin A, and stimulating anorexigenic peptides such as proopiomelanocortin. White fat also secretes several putative appetite-related adipokines, which include interleukin-6 and adiponectin, but whether these are indeed significant signals in the regulation of food intake has not been established. Through leptin and the other adipokines it is evident that adipose tissue communicates extensively with other organs and plays a pervasive role in metabolic homeostasis
Fibred knots and disks with clasps.
It is known that every closed, orientable 3-manifold contains a fi-bered knot—a simple closed curve whose complement is a surface bundle over S1. For K such a fibered knot in a rational homology 3-sphere M it is shown that for any compact submanifold X of M containing K as a null-homologous subset, each component of ∂X is compressible in M−K. If K is a doubled knot (bounds a disk with one clasp) then it follows that K is a double of the trivial knot. More generally, it follows that the genus of X (minimum number of one-handles) is less than the genus of M
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